Termination of chronic daily glucocorticoid therapy (longer than 2 weeks) should be gradual - both to prevent development of adrenal insufficiency and to avoid reactivation of the disease under therapy. The likelihood of the latter depends on the activity and natural history of the disorder. When there is any chance that the underlying illness may recur, the glucocorticoids should be withdrawn slowly over a period of weeks to months with frequent reassessment of the patient's condition. Daily hydrocortisone replacement or double or triple replacement of intermediate-acting glucocorticoids given on alternate days are acceptable methods for weaning patients from glucocorticoid therapy (6).