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	INTRODUCTION
	CYTOKINE PRODUCTION AND Th1/Th2 BALANCE
	Glucocorticoids and catecholamines
	Estrogen and progesterone
	1, 25- Dihydroxyvitamin D3
	Histamine
	Adenosine
	Peptidergic/ sensory nerves
	Parasympathetic (cholinergic) system
	Local vs. systemic effects
	CRH/ SP- mast cell-histamine axis
	ANTIGEN PRESENTATION
	Lymphocyte traffic and proliferation
	Antibody production
	CONCLUSIONS AND CLINICAL IMPLICATIONS