1. Vgontzas AN, Kales A. Sleep and its disorders. Annu Rev Med 1999;50:387-400
2. Borbely AA: A two process model of sleep regulation. Hum Neurobiol 1:195-204, 1982
3. Czeisler CA, Weitzman ED, Moore-Ede MC, Zimmerman JC, Knauer RS. Human sleep: its duration and organization depend on its circadian phase. Science 210:1264-1267, 1980
4. Rechtschaffen A, Kales A: A Manual of Standardized Terminology, Techniques, and Scoring System for Sleep Stages of Human Subjects, Bethesda: National Institutes of Health, NIH Rep No 204; 1968
5. Bixler EO, Kales A, Soldatos CR, Kales JD, Healey S: Prevalence of sleep disorders in the Los Angeles metropolitan area. Am J Psychiatry 1136:1257-1262, 1979
6. Lugaresi E, Cirignotta F, Zucconi M, et al: Good and poor sleepers: An epidemiological survey of the San Marino population, In Guilleminault C, Lugaresi C (eds): Sleep/Wake Disorders: Natural History, Epidemiology and Long-Term Evoluation, New York: Plenum Press (pp. 1-12), 1983
7. Kales A, Kales J: Evaluation and Treatment of Insomnia, New York, Oxford University Press, 1984
8. Buysse DJ, Reynolds CF III, Hauri PJ, Roth T, Stepanski EJ, Thorpy MJ, et al: Diagnostic concordance for DSM-IV sleep disorders: A report from the APA/ NIMH DSM-IV field trial. Am J Psychiatry 151:1351-1360, 1994
9. Ford DE, Kamerow DB: Epidemiologic study of sleep disturbances and psychiatric disorders. JAMA 262:1479-1484, 1989
10. Vgontzas AN, Bixler EO, Tan TL, Kantner D, Martin LF, Kales A: Obesity without sleep apnea is associated with daytime sleepiness. Arch Intern Med 158:1333-1337, 1998
11. Bixler EO, Vgontzas AN, Lin H, Leiby B, Kales A: Excessive daytime sleepiness: association with diabetes. Endocrine Society's 83rd Annual Meeting, Denver, CO, June 20-23, 2001
12. Chrousos GP: The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 332:1351-1362, 1995
13. Chrousos GP, Gold PW: The concepts of stress and stress system disorders. JAMA 267:1244-1252, 1992
14. Chrousos GP, Loriaux DL, Gold PW (eds): Mechanisms of Physical and Emotional Stress. Advances in Experimental Medicine and Biology, New York: Plenum Press, Vol. 245, 1988
15. Weitzman ED, Zimmerman JC, Czeisler CA: Cortisol secretion is inhibited during sleep in normal man. J Clin Endocrinol Metab 56:352, 1983
16. Opp M: Corticotropin-releasing hormone involvement in stressor-induced alterations in sleep and in the regulation of waking. Adv Neuroimmunol 5:127-143, 1995
17. Opp M, Obál Jr F, Krueger JM: Corticotropin-releasing factor attenuates interleukin 1-induced sleep and fever in rabbits. Am J Physiol 257:R528-R535, 1989
18. Chrousos GA, Kattah JC, Beck RW, Cleary PA: Side effects of glucocorticoid treatment. JAMA 269:2110-2112, 1993
19. Born J, Kern W, Bieber K, Fehm-Wolfsdorf G, Schiebe M, Fehm HL: Night-time plasma cortisol secretion is associated with specific sleep stages. Biol Psychiatry 21:1415-1424, 1986
20. Follenius M, Brandenberger G, Bandesapt JJ, Libert JP, Ehrhart J: Nocturnal cortisol release in relation to sleep structure. Sleep 15:21-27, 1992
21. Späth-Schwalbe E, Gofferje M, Kern W, Born J, Fehm HL: Sleep disruption alters nocturnal ACTH and cortisol secretory patterns. Biol Psychiatry 29:575-584, 1991
22. Steiger A, Holsboer F: Neuropeptides and human sleep. Sleep 20:1038-1052, 1997
23. Mandell MP, Mandell AJ, Rubtin RT, Brill P, Rodnick J, Sheff R, et al: Activation of the pituitary-adrenal axis during rapid eye movement sleep in man. Life Sci 5:583-587, 1966
24. Vgontzas AN, Bixler EO, Papanicolaou, Kales A, Stratakis CA, Vela-Bueno A, et al: Rapid eye movement sleep correlates with the overall activities of the hypothalamic-pituitary-adrenal axis and sympathetic system in healthy humans. J Clin Endocrinol Metab 82:3278-3280, 1997
25. Born J, Spath-Schwalbe E, Schwakenhofer H, Kem W, Fehm HL: Influences of corticotropin-releasing hormone, adreno-corticotropin, and cortisol on sleep in normal man. J Clin Endocrinol Metab 68:904-911, 1989
26. Kellner M, Yassouridis A, Manz B, Steiger A, Holsboer F, Wiedemann K: Corticotropin-releasing hormone inhibits melatonin secretion in healthy volunteers: A potential link to low-melatonin syndrome in depression? Neuroendocrinology 65:284-290, 1997
27. Mann K, Roschke J, Benkert O, Aldenhoff J, Nink M, Beyer J, et al: Effects of corticotropin-releasing hormone on respiratory parameters during sleep in normal men. Exp Clin Endocrinol Diabetes 103:233-240, 1995
28. Vgontzas AN, Bixler EO, Wittman AM, Zachman K, Lin H, Vela-Bueno A, et al: Middle-aged men show higher sensitivity of sleep to the arousing effects of corticotropin-releasing hormone than young men: Clinical implications. J Clin Endocrinol Metab 86:1489-1495, 2001
29. Gillin JC, Jacobs LS, Fram DH, Snyder F: Acute effect of a glucocorticoid on normal human sleep. Nature 237:398-399, 1972
30. Steiger A, Antonijevic A, Bohlhalter S, Frieboes RM, Friess E, Murck H: Effects of hormones on sleep. Horm Res 49:125-130, 1998
31. García-Borreguero D, Wehr TA, Larrosa O, Granizo JJ, Hardwick D, Chrousos GP, et al: Glucocorticoid replacement is permissive for rapid eye movement sleep and sleep consolidation in patients with adrenal insufficiency. J Clin Endocrinol Metab 85:4201-4206, 2000
32. Van Cauter E, Leproult R, Plat L: Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men. JAMA 284(7):861-868, 2000
33. Van Cauter E, Leproult R, Kupfer DJ: Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol. J Clin Endocrinol Metab 81:2468-2473, 1996
34. Vgontzas AN, Zoumakis M, Bixler EO, Lin H, Prolo P, Vela-Bueno A, Kales A, Chrousos GP: Impaired nighttime sleep in healthy old vs. young adults is associated with elevated plasma IL-6 and cortisol levels: physiologic and therapeutic implications. J Clin Endocrinol Metab (in press)
35. Prinz P, Bailey S, Moe, K: Urinary free cortisol and sleep under baseline and stressed conditions in healthy senior women: Effects of estrogen replacement therapy. J Sleep Res 10:19-26, 2001
36. Brun J, Chamba G, Kihalfallah Y, Girard P, Boissy I, Bastuji H, et al: Effect of modafinil on plasma melatonin, cortisol and growth hormone rhythms, rectal temperature and performance in healthy subjects during a 36 h sleep deprivation. J Sleep Res 7:105-114, 1998
37. Moldofsky H, Lue FA, Davidson JR, Gorczynski R: Effects of sleep deprivation on human immune functions. FASEB J 3:1927-1977, 1989
38. Scheen AJ, Byrne MM, Plat L, Leproult R, Van Cauter E: Relationships between sleep quality and glucose regulation in normal humans. Am J Physiol 271 (Endocrinology Metabolism 34) E261-E270, 1996
39. Leproult R, Copinschi G, Buxton O, Van Cauter E: Sleep loss result in an elevation of cortisol levels the next evening. Sleep 20:865-870, 1997
40. Vgontzas AN, Mastorakos G, Bixler EO, Kales A, Gold PW, Chrousos GP: Sleep deprivation effects on the activity of the hypothalamic-pituitary-adrenal and growth axes: Potential clinical implications. Endocrinol 51:205-215, 1999
41. Spiegel K, Leproult R, Van Cauter E: Impact of sleep debt on metabolic and endocrine function. Lancet 354(9188):1435-1439, 1999
42. Vgontzas AN, Zoumakis E, Bixler EO, Lin HM, Follett H, Chrousos P: Effects of one week of modest sleep restriction to 6 hours per night on daytime sleepiness, performance, IL-6, TNF, and cortisol plasma levels. Endocrine Society's 84th Annual Meeting, San Francisco, CA, June, 2002
43. Rechtschaffen A, Bergmann BM, Everson CA, Kushida CA, Gilliland MA: Sleep deprivation in the rat. X. Integration and discussion of the findings. Sleep 12:68-87, 1989
44. Adams K, Tomeny M, Oswald I: Physiological and psychological differences between good and poor sleepers. J Psychiatric Res 20:301-316, 1986
45. Vgontzas AN, Tsigos C, Bixler EO, Stratakis CA, Zachman K, Kales A, et al: Chronic insomnia and activity of the stress system: A preliminary study. J Psychosom Res 45(1):21-31, 1998
46. Vgontzas AN, Bixler EO, Lin H-M, Prolo P, Mastorakos G, Vela-Bueno A, et al: Chronic insomnia is associated with nyctohemeral activation of the hypothalamic-pituitary-adrenal axis: clinical implications. J Clin Endocrinol Metab 86:3787-3794, 2001
47. Rodenbeck A, Heuther G, Ruther E, Hajak G: Interactions between evening and nocturnal cortisol secretion and sleep parameters in patients with severe chronic primary insomnia: Neurosci Lett 324(2):154-163, 2002
48. Riemann D, Klein T, Rodenbeck A, Feige B, Horny A, Hummel R, Weske G, Al-Shajlawi A, Voderholzer U: Nocturnal cortisol and melatonin secretion in primary insomnia. Psychiatry Research 113:17-27, 2002
49. Bixler EO, Vgontzas AN, Lin HM, Vela-Bueno A, Kales A: Insomnia in central Pennsylvania. J Psychosom Res 53(1):589-592, 2002
50. Michelson D, Galliven E, Hill L, Demitrack M, Chrousos G, Gold P: Chronic imipramine is associated with diminished hypothalamic-pituitary-adrenal axis responsivity in healthy humans. J Clin Endocrinol Metab 82:2610-2606, 1997
51. Hajak G, Rodenbeck A, Adler L, Huether G, Bandelow B, Herrendorf G: Nocturnal melatonin secretion and sleep after doxepin administration in chronic primary insomnia. Pharmacopsychiatry 29:187-192, 1996
52. Hohagen F, Montero RF, Weiss E, Lis S, Schonbrunn E, Dressing H, et al: Treatment of primary insomnia with trimipramine: An alternative to benzodiazepine hypnotics? Eur Arch Psychiatry Clin Neurosci 224:65-72, 1994
53. Fletcher EC, Miller J, Schaaf JW, Fletcher JG: Urinary catecholamines before and after tracheostomy in patients with obstructive sleep apnea and hypertension. Sleep 10:35-44, 1987
54. Waradekar NV, Sinoway LI, Zwillich CW, Leuenberger UA: Influence of treatment on muscle sympathetic nerve activity in sleep apnea. Am J Respir Crit Care Med 153:1333-1338, 1996
55. Entzian P, Linnemann K, Schlaak M, Zabel P: Obstructive sleep apnea syndrome and circadian rhythms of hormones and cytokines. Am J Respir Crit Care Med 153:1080-1086, 1996
56. Guilleminault C, Dement WC: Sleep Apnea Syndromes, New York: Alan R Liss, 1978
57. Grunstein RR, Stewart DA, Lloyd H, Akinci M, Cheng N, Sullivan CE: Acute withdrawal of nasal CPAP in obstructive sleep apnea does not cause a rise in stress hormones. Sleep 19(10):774-782, 1996
58. Vgontzas AN, Papanicolaou DA, Bixler EO, Kales A, Vela-Bueno A, Myers D, et al: Evidence of corticotropin-releasing hormone (CRH) deficiency in patients with idiopathic hypersomnia: Clinical and pathophysiological implications. Endocrine Society's 79th Annual Meeting, Minneapolis, MN, June 11-14, 1997
59. Kok SW, Roelfsema F, Overeem S, Lammers GJ, Strijers RL, Frölich M, Meinders AE, Pijl H: Dynamics of the pituitary-adrenal ensemble in hypocretin-deficient narcoleptic humans: blunted basal adrenocorticotropin release and evidence for normal time-keeping by the master pacemaker. J Clin Endocrinol Metab 87(11):5085-91, 2002
60. Shipley JE, Schteingart DE, Tandon R, Starkman MN. Sleep architecture and sleep apnea in patients with Cushing's disease. Sleep 15:514-518, 1992
61. Vgontzas AN, Papanicolaou DA, Bixler EO, Hopper K, Lotsikas A, Lin H, et al: Sleep apnea and daytime sleepiness and fatigue: Relation to visceral obesity, insulin resistance, and hypercytokinemia. J Clin Endocrinol Metab 85:1151-1158, 2000
62. Friedman TC, García-Borreguero D, Hardwick D, Akuete CN, Doppman JL, Dorn LD, et al: Decreased delta-sleep and plasma delta-sleep-inducing peptide in patients with Cushing syndrome. Neuroendocrinology 60:626-634, 1994
63. Papanicolaou DA, Tsigos C, Oldfield EH, Chrousos GP: Acute glucocorticoid deficiency is associated with plasma elevations of interleukin-6: Does the latter participate in the symptomatology of the steroid withdrawal syndrome and adrenal insufficiency? J Clin Endocrinol Metab 81:2303-2306, 1996
64. Reincke M, Heppner C, Petzke F, Allolio B, Arlt W, Mbulamberi D, et al: Impairment of adrenocortical function associated with increased plasma tumor necrosis factor-alpha and interleukin-6 concentrations in African trypanosomiasis. Neuroimmunomodulation 1:14-22, 1994
65. Chrousos GP: The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 332(20):1351-1362, 1995
66. Krueger JM, Walter J, Dinarello CA, Wolff SM, Chedid L: Sleep-promoting effects of endogenous pyrogen (interleukin-1). Am J Physiol 246:R994-R999, 1984
67. Tobler I, Borbély AA, Schwyzer M, Fontana A: Interleukin-1 derived from astrocytes enhances slow wave activity in sleep EEG of the rat. Eur J Pharmacol 104:191-192, 1984
68. Fontana A, Kristensen F, Dubs R, Gemsa D, Weber E: Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells. J Immunol 129:2413-2419, 1982
69. Shoham S, Davenne D, Cady AB, Dinarello CA, Krueger JM: Recombinant tumor necrosis factor and interleukin 1 enhance slow-wave sleep. Am J Physiol 253:R142-R149, 1987
70. Walter JS, Meyers P, Krueger JM: Microinjection of interleukin-1 into brain: Separation of sleep and fever responses. Physiol Behav 45:169-176, 1989
71. Kapás L, Krueger JM: Tumor necrosis factor-beta induces sleep, fever, and anorexia. Am J Physiol 263:R703-R707, 1992
72. Bredow S, Taishi P, Guha-Thakurta N, Obal F Jr, Krueger JM: Diurnal variations of tumor necrosis factor-a mRNA anda-tubulin mRNA in rat brain. Neuroimmunomodulation 4:84-90, 1997
73. Floyd RA, Krueger JM: Diurnal variation of TNFa in the rat brain. NeuroReport 8:915-918, 1997
74. Takahashi S, Kapás L, Fang L, Krueger JM: An anti-tumor necrosis factor antibody suppresses sleep in rats and rabbits. Brain Res 690:241-244, 1995
75. Fang J, Wang Y, Krueger JM: Mice lacking the TNF 55 kDa receptor fail to sleep more after TNFa treatment. J Neurosci 17:5949-5955, 1997
76. Moldofsky H, Lue FA, Eisen J, Keystone E, Gorczynski RM: The relationship of interleukin-1 and immune functions to sleep in humans. Psychosom Med 48:309-318, 1986
77. Darko DF, Miller JC, Gallen C, White J, Koziol J, Brown SJ, et al: Sleep electroencephalogram delta frequency amplitude, night plasma levels of tumor necrosis factor a and human immunodeficiency virus infection. Proc Natl Acad Sci U S A 92:12080-12086, 1995
78. Covelli V, D'Andrea L, Savastano S, Valentino R, Tommaselli AP, Selleri A, et al: Interleukin-1 beta plasma secretion during diurnal spontaneous and induces sleeping in healthy volunteers. Acta Neurol (Napoli) 16:79-86, 1994
79. Gudewill S, Pollmacher T, Vedder H, Schreiber W, Fassbender K, Holsboer F: Nocturnal plasma levels of cytokines in healthy men. Eur Arch Psychiatry Clin Neurosci 242:53-56, 1992
80. Vgontzas AN, Papanicolaou DA, Bixler EO, Lotsikas A, Zachman K, Kales A, et al: Circadian interleukin-6 secretion and quantity and depth of sleep. J Clin Endocrinol Metab 84:2603-2607, 1999
81. Bauer J, Hohagen T, Ebert J, Timmer J, Ganter U, Krieger S, et al: Interleukin-6 serum levels in healthy persons correspond to the sleep-wake cycle. Clin Invest 72:315, 1994
82. Crofford LJ, Kalogeras KT, Mastorakos G, Magiakou MA, Wells J, Kanik KS, et al: Circadian relationships between interleukin (IL-6) and hypothalamic-pituitary-adrenal axis hormones: Failure of IL-6 to cause sustained hypercortisolism in patients with early untreated rheumatoid arthritis. J Clin Endocrinol Metab 82:1279-1283, 1997
83. Sothern RB, Roitman-Johnson B, Kanabrock EL, Yager JG, Fuerstenberg RR, Weatherbee JA, et al: Circadian characteristics of interleukin-6 in blood and urine of clinically healthy men. In Vivo 9:331-340, 1995
84. Fernandez-Real, J-M, Vayreda M, Richart C, Gutierrez C, Broch M, Vendrell J, et al: Circulating interleukin-6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women. J Clin Endocrinol Metab 86:1154-1159, 2001
85. Papanicolaou DA, Wilder RL, Manolagas SC, Chrousos GP: The pathophysiologic roles of interleukin-6 in human disease. Ann Intern Med 128:127-137, 1998
86. Mastorakos G, Chrousos GP, Weber JS: Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans. J Clin Endocrinol Metab 77:1690-1694, 1993
87. Späth-Schwalbe E, Hansen K, Schmidt F, Schrezenmeier H, Marshall L, Burger K, et al: Acute effects of recombinant human interleukin-6 on endocrine and central nervous sleep functions in healthy men. J Clin Endocrinol Metab 83:1578-1579, 1998
88. Vgontzas AN, Zoumakis M, Bixler EO, Lin H, Prolo P, Vela-Bueno A, Kales A, Chrousos GP: Impaired nighttime sleep in healthy old versus young adults is associated with elevated plasma interleukin-6 and cortisol levels: physiologic and therapeutic implications. J Clin Endocrinol Metab (in press)
89. Ershler WB, Keller ET (Review): Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu Rev Med 51:245-70, 2000
90. Vgontzas AN, Zoumakis M, Papanicolaou DA, Bixler EO, Prolo P, Lin HM, et al: Chronic insomnia is associated with a shift of IL-6 and TNFa secretion from nighttime to daytime. Metabolism 51(7):887-92, 2002
91. Vgontzas AN, Chrousos GP: Sleep, the hypothalamic-pituitary-adrenal axis and cytokines: multiple interactions and disturbances in sleep disorders. Endocrinol Metab Clin N Am 31:15-36, 2002
92. Gold PW, Chrousos GP: Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs. low CRH/NE states. Molecular Psychiatry 7:254-275, 2002
93. Chrousos GP, Gold PW: A healthy body in a healthy mind - vice versa -: the damaging power of "uncontrollable" stress (Editorial). J Clin Endocrinol Metab 83:1842-1845, 1998
94. Clauw DJ, Chrousos GP: Chronic pain and fatigue syndromes: overlapping clinical and neuroendocrine features and potential pathogenic mechanisms. Neuroimmunomodulation 4:134-153, 1997
95. Partinen M: Sleeping habits and sleep disorders of Finnish men before, during, and after military service. Ann Med Milit Fenn 57(suppl):96, 1982
96. Vgontzas AN, Papanicolaou DA, Bixler EO, Kales A, Tyson K, Chrousos GP: Elevation of plasma cytokines in disorders of excessive daytime sleepiness: Role of sleep disturbance and obesity. J Clin Endocrinol Metab 82:1313-1316, 1997
97. Hinze-Selch D, Wetter TC, Zhang Y, Lu HC, Albert ED, Mullington J: In vivo and in vitro immune variables in patients with narcolepsy and HLA-DR2 matched controls. Neurology 50(4):1149-1152, 1998
98. Shearer WT, Reuben JM, Mullington JM, et al.: Soluble TNF-alpha receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight. J Allergy Clin Immunol 107(1):19-20, 2001
99. Redwine L, Hauger RL, Gillin JC, Irwin M: Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans. J Clin Endocrinol Metab 85:3597-3603, 2000
100. Bonnett MH, Arand DL: The consequences of a week of insomnia. Sleep 19:453-461, 1996
101. Stepanski E, Zorick F, Roehrs T, Young D, Roth T: Daytime alertness in patients with chronic insomnia compared with asymptomatic control subjects. Sleep 11:54-60, 1988
102. Mullington JC, Korth D, Hermann A, et al.: Dose-dependent effects of endotoxin on human sleep. Am J Physiol 278:R947-955, 2000