1. American Diabetes Association. Diabetes 1996 vital statistics. 1996. Alexandria, VA, American Diabetes Association.
2. King,H, Aubert,RE, Herman,WH: Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care 21:1414-1431, 1998
3. Zimmet,P, Alberti,KG, Shaw,J: Global and societal implications of the diabetes epidemic. Nature 414:782-787, 2001
4. Felber,JP, Golay,A: Pathways from obesity to diabetes. Int.J.Obes.Relat Metab Disord. 26 Suppl 2:S39-S45, 2002
5. Youngren,JF, Keen,S, Kulp,JL, Tanner,CJ, Houmard,JA, Goldfine,ID: Enhanced muscle insulin receptor autophosphorylation with short-term aerobic exercise training. Am.J.Physiol Endocrinol.Metab 280:E528-E533, 2001
6. Youngren,JF, Paik,J, Barnard,RJ: Impaired insulin-receptor autophosphorylation is an early defect in fat-fed, insulin-resistant rats. J.Appl.Physiol 91:2240-2247, 2001
7. Kawate,R, Yamakido,M, Nishimoto,Y, Bennett,PH, Hamman,RF, Knowler,WC: Diabetes mellitus and its vascular complications in Japanese migrants on the Island of Hawaii. Diabetes Care 2:161-170, 1979
8. Helmrich,SP, Ragland,DR, Leung,RW, Paffenbarger,RS, Jr.: Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N.Engl.J.Med. 325:147-152, 1991
9. Manson,JE, Nathan,DM, Krolewski,AS, Stampfer,MJ, Willett,WC, Hennekens,CH: A prospective study of exercise and incidence of diabetes among US male physicians. JAMA 268:63-67, 1992
10. Manson,JE, Rimm,EB, Stampfer,MJ, Colditz,GA, Willett,WC, Krolewski,AS, Rosner,B, Hennekens,CH, Speizer,FE: Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet 338:774-778, 1991
11. Hu,FB, Sigal,RJ, Rich-Edwards,JW, Colditz,GA, Solomon,CG, Willett,WC, Speizer,FE, Manson,JE: Walking compared with vigorous physical activity and risk of type 2 diabetes in women: a prospective study. JAMA 282:1433-1439, 1999
12. Knowler,WC, Barrett-Connor,E, Fowler,SE, Hamman,RF, Lachin,JM, Walker,EA, Nathan,DM: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N.Engl.J.Med. 346:393-403, 2002
13. The Diabetes Prevention Program. Design and methods for a clinical trial in the prevention of type 2 diabetes. Diabetes Care 22:623-634, 1999
14. Tuomilehto,J, Lindstrom,J, Eriksson,JG, Valle,TT, Hamalainen,H, Ilanne-Parikka,P, Keinanen-Kiukaanniemi,S, Laakso,M, Louheranta,A, Rastas,M, Salminen,V, Uusitupa,M: Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N.Engl.J.Med. 344:1343-1350, 2001
15. Li,G, Hu,Y, Yang,W, Jiang,Y, Wang,J, Xiao,J, Hu,Z, Pan,X, Howard,BV, Bennett,PH: Effects of insulin resistance and insulin secretion on the efficacy of interventions to retard development of type 2 diabetes mellitus: the DA Qing IGT and Diabetes Study. Diabetes Res.Clin.Pract. 58:193-200, 2002
16. Cartee,GD, Douen,AG, Ramlal,T, Klip,A, Holloszy,JO: Stimulation of glucose transport in skeletal muscle by hypoxia. J.Appl.Physiol 70:1593-1600, 1991
17. Gao,J, Ren,J, Gulve,EA, Holloszy,JO: Additive effect of contractions and insulin on GLUT-4 translocation into the sarcolemma. J.Appl.Physiol 77:1597-1601, 1994
18. Goodyear,LJ, King,PA, Hirshman,MF, Thompson,CM, Horton,ED, Horton,ES: Contractile activity increases plasma membrane glucose transporters in absence of insulin. Am.J.Physiol 258:E667-E672, 1990
19. Douen,AG, Ramlal,T, Rastogi,S, Bilan,PJ, Cartee,GD, Vranic,M, Holloszy,JO, Klip,A: Exercise induces recruitment of the "insulin-responsive glucose transporter". Evidence for distinct intracellular insulin- and exercise- recruitable transporter pools in skeletal muscle. J.Biol.Chem. 265:13427-13430, 1990
20. Coderre,L, Kandror,KV, Vallega,G, Pilch,PF: Identification and characterization of an exercise-sensitive pool of glucose transporters in skeletal muscle. J.Biol.Chem. 270:27584-27588, 1995
21. Kristiansen,S, Hargreaves,M, Richter,EA: Exercise-induced increase in glucose transport, GLUT-4, and VAMP-2 in plasma membrane from human muscle. Am.J.Physiol 270:E197-E201, 1996
22. Cormont,M, Tanti,JF, Zahraoui,A, Van Obberghen,E, Tavitian,A, Marchand-Brustel,Y: Insulin and okadaic acid induce Rab4 redistribution in adipocytes. J.Biol.Chem. 268:19491-19497, 1993
23. Treadway,JL, James,DE, Burcel,E, Ruderman,NB: Effect of exercise on insulin receptor binding and kinase activity in skeletal muscle. Am.J.Physiol 256:E138-E144, 1989
24. Goodyear,LJ, Giorgino,F, Balon,TW, Condorelli,G, Smith,RJ: Effects of contractile activity on tyrosine phosphoproteins and PI 3- kinase activity in rat skeletal muscle. Am.J.Physiol 268:E987-E995, 1995
25. Wojtaszewski,JF, Hansen,BF, Urso,B, Richter,EA: Wortmannin inhibits both insulin- and contraction-stimulated glucose uptake and transport in rat skeletal muscle. J.Appl.Physiol 81:1501-1509, 1996
26. Lee,AD, Hansen,PA, Holloszy,JO: Wortmannin inhibits insulin-stimulated but not contraction-stimulated glucose transport activity in skeletal muscle. FEBS Lett. 361:51-54, 1995
27. Yeh,JI, Gulve,EA, Rameh,L, Birnbaum,MJ: The effects of wortmannin on rat skeletal muscle. Dissociation of signaling pathways for insulin- and contraction-activated hexose transport. J.Biol.Chem. 270:2107-2111, 1995
28. Lund,S, Holman,GD, Schmitz,O, Pedersen,O: Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin. Proc.Natl.Acad.Sci.U.S.A 92:5817-5821, 1995
29. Brozinick,JT, Jr., Etgen,GJ, Jr., Yaspelkis,BB, III, Ivy,JL: Contraction-activated glucose uptake is normal in insulin-resistant muscle of the obese Zucker rat. J.Appl.Physiol 73:382-387, 1992
30. Dolan,PL, Tapscott,EB, Dorton,PJ, Dohm,GL: Contractile activity restores insulin responsiveness in skeletal muscle of obese Zucker rats. Biochem.J. 289 ( Pt 2):423-426, 1993
31. King,PA, Betts,JJ, Horton,ED, Horton,ES: Exercise, unlike insulin, promotes glucose transporter translocation in obese Zucker rat muscle. Am.J.Physiol 265:R447-R452, 1993
32. Kern,M, Wells,JA, Stephens,JM, Elton,CW, Friedman,JE, Tapscott,EB, Pekala,PH, Dohm,GL: Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level. Biochem.J. 270:397-400, 1990
33. Cleland,PJ, Appleby,GJ, Rattigan,S, Clark,MG: Exercise-induced translocation of protein kinase C and production of diacylglycerol and phosphatidic acid in rat skeletal muscle in vivo. Relationship to changes in glucose transport. J.Biol.Chem. 264:17704-17711, 1989
34. Wojtaszewski,JF, Laustsen,JL, Derave,W, Richter,EA: Hypoxia and contractions do not utilize the same signaling mechanism in stimulating skeletal muscle glucose transport. Biochim.Biophys.Acta 1380:396-404, 1998
35. Ihlemann,J, Galbo,H, Ploug,T: Calphostin C is an inhibitor of contraction, but not insulin-stimulated glucose transport, in skeletal muscle. Acta Physiol Scand. 167:69-75, 1999
36. Balon,TW, Nadler,JL: Nitric oxide release is present from incubated skeletal muscle preparations. J.Appl.Physiol 77:2519-2521, 1994
37. Roberts,CK, Barnard,RJ, Jasman,A, Balon,TW: Acute exercise increases nitric oxide synthase activity in skeletal muscle. Am.J.Physiol 277:E390-E394, 1999
38. Young,ME, Radda,GK, Leighton,B: Nitric oxide stimulates glucose transport and metabolism in rat skeletal muscle in vitro. Biochem.J. 322 ( Pt 1):223-228, 1997
39. Smith,LW, Smith,JD, Criswell,DS: Involvement of nitric oxide synthase in skeletal muscle adaptation to chronic overload. J.Appl.Physiol 92:2005-2011, 2002
40. Balon, T. W., Jasman, A., Balon, E. C., and Nadler, J. L. Skeletal muscle glucose tranport is mediated by nitric oxide via a cGMP-related mechanism. Med.Sci Sports Exerc. 28, S58. 1996.
41. Etgen,GJ, Jr., Fryburg,DA, Gibbs,EM: Nitric oxide stimulates skeletal muscle glucose transport through a calcium/contraction- and phosphatidylinositol-3-kinase-independent pathway. Diabetes 46:1915-1919, 1997
42. Roberts,CK, Barnard,RJ, Scheck,SH, Balon,TW: Exercise-stimulated glucose transport in skeletal muscle is nitric oxide dependent. Am.J.Physiol 273:E220-E225, 1997
43. Higaki,Y, Hirshman,MF, Fujii,N, Goodyear,LJ: Nitric oxide increases glucose uptake through a mechanism that is distinct from the insulin and contraction pathways in rat skeletal muscle. Diabetes 50:241-247, 2001
44. Richter,EA, Derave,W, Wojtaszewski,JF: Glucose, exercise and insulin: emerging concepts. J.Physiol 535:313-322, 2001
45. Rasmussen,BB, Winder,WW: Effect of exercise intensity on skeletal muscle malonyl-CoA and acetyl- CoA carboxylase. J.Appl.Physiol 83:1104-1109, 1997
46. Hutber,CA, Hardie,DG, Winder,WW: Electrical stimulation inactivates muscle acetyl-CoA carboxylase and increases AMP-activated protein kinase. Am.J.Physiol 272:E262-E266, 1997
47. Hardie,DG, Carling,D, Carlson,M: The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu.Rev.Biochem. 67:821-855, 1998
48. Winder,WW, Hardie,DG: Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise. Am.J.Physiol 270:E299-E304, 1996
49. Chen,ZP, Mitchelhill,KI, Michell,BJ, Stapleton,D, Rodriguez-Crespo,I, Witters,LA, Power,DA, Ortiz de Montellano,PR, Kemp,BE: AMP-activated protein kinase phosphorylation of endothelial NO synthase. FEBS Lett. 443:285-289, 1999
50. Chen,ZP, McConell,GK, Michell,BJ, Snow,RJ, Canny,BJ, Kemp,BE: AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation. Am.J.Physiol Endocrinol.Metab 279:E1202-E1206, 2000
51. Hayashi,T, Hirshman,MF, Kurth,EJ, Winder,WW, Goodyear,LJ: Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport. Diabetes 47:1369-1373, 1998
52. Sakamoto,K, Goodyear,LJ: Invited review: intracellular signaling in contracting skeletal muscle. J.Appl.Physiol 93:369-383, 2002
53. Boppart,MD, Asp,S, Wojtaszewski,JF, Fielding,RA, Mohr,T, Goodyear,LJ: Marathon running transiently increases c-Jun NH2-terminal kinase and p38 activities in human skeletal muscle. J.Physiol 526 Pt 3:663-669, 2000
54. Yu,M, Blomstrand,E, Chibalin,AV, Krook,A, Zierath,JR: Marathon running increases ERK1/2 and p38 MAP kinase signalling to downstream targets in human skeletal muscle. J.Physiol 536:273-282, 2001
55. Goodyear,LJ, Chang,PY, Sherwood,DJ, Dufresne,SD, Moller,DE: Effects of exercise and insulin on mitogen-activated protein kinase signaling pathways in rat skeletal muscle. Am.J.Physiol 271:E403-E408, 1996
56. Boppart,MD, Hirshman,MF, Sakamoto,K, Fielding,RA, Goodyear,LJ: Static stretch increases c-Jun NH2-terminal kinase activity and p38 phosphorylation in rat skeletal muscle. Am.J.Physiol Cell Physiol 280:C352-C358, 2001
57. Wretman,C, Lionikas,A, Widegren,U, Lannergren,J, Westerblad,H, Henriksson,J: Effects of concentric and eccentric contractions on phosphorylation of MAPK(erk1/2) and MAPK(p38) in isolated rat skeletal muscle. J.Physiol 535:155-164, 2001
58. Schneider,SH, Khachadurian,AK, Amorosa,LF, Gavras,H, Fineberg,SE, Ruderman,NB: Abnormal glucoregulation during exercise in type II (non-insulin- dependent) diabetes. Metabolism 36:1161-1166, 1987
59. Giacca,A, Groenewoud,Y, Tsui,E, McClean,P, Zinman,B: Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia. Diabetes 47:1763-1770, 1998
60. Larsen,JJ, Dela,F, Kjaer,M, Galbo,H: The effect of moderate exercise on postprandial glucose homeostasis in NIDDM patients. Diabetologia 40:447-453, 1997
61. Larsen,JJ, Dela,F, Madsbad,S, Vibe-Petersen,J, Galbo,H: Interaction of sulfonylureas and exercise on glucose homeostasis in type 2 diabetic patients. Diabetes Care 22:1647-1654, 1999
62. Hallsten,K, Virtanen,KA, Lonnqvist,F, Sipila,H, Oksanen,A, Viljanen,T, Ronnemaa,T, Viikari,J, Knuuti,J, Nuutila,P: Rosiglitazone but not metformin enhances insulin- and exercise-stimulated skeletal muscle glucose uptake in patients with newly diagnosed type 2 diabetes. Diabetes 51:3479-3485, 2002
63. Kjaer,M, Hollenbeck,CB, Frey-Hewitt,B, Galbo,H, Haskell,W, Reaven,GM: Glucoregulation and hormonal responses to maximal exercise in non- insulin-dependent diabetes. J.Appl.Physiol 68:2067-2074, 1990
64. Larsen,JJ, Dela,F, Madsbad,S, Galbo,H: The effect of intense exercise on postprandial glucose homeostasis in type II diabetic patients. Diabetologia 42:1282-1292, 1999
65. Sonnenberg,GE, Kemmer,FW, Berger,M: Exercise in type 1 (insulin-dependent) diabetic patients treated with continuous subcutaneous insulin infusion. Prevention of exercise induced hypoglycaemia. Diabetologia 33:696-703, 1990
66. Mitchell,TH, Abraham,G, Schiffrin,A, Leiter,LA, Marliss,EB: Hyperglycemia after intense exercise in IDDM subjects during continuous subcutaneous insulin infusion. Diabetes Care 11:311-317, 1988
67. Perseghin,G, Price,TB, Petersen,KF, Roden,M, Cline,GW, Gerow,K, Rothman,DL, Shulman,GI: Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. N.Engl.J.Med. 335:1357-1362, 1996
68. Devlin,JT, Hirshman,M, Horton,ED, Horton,ES: Enhanced peripheral and splanchnic insulin sensitivity in NIDDM men after single bout of exercise. Diabetes 36:434-439, 1987
69. Burstein,R, Epstein,Y, Shapiro,Y, Charuzi,I, Karnieli,E: Effect of an acute bout of exercise on glucose disposal in human obesity. J.Appl.Physiol 69:299-304, 1990
70. Mikines,KJ, Sonne,B, Farrell,PA, Tronier,B, Galbo,H: Effect of physical exercise on sensitivity and responsiveness to insulin in humans. Am.J.Physiol 254:E248-E259, 1988
71. Gulve,EA, Cartee,GD, Zierath,JR, Corpus,VM, Holloszy,JO: Reversal of enhanced muscle glucose transport after exercise: roles of insulin and glucose. Am.J.Physiol 259:E685-E691, 1990
72. Cartee,GD, Young,DA, Sleeper,MD, Zierath,J, Wallberg-Henriksson,H, Holloszy,JO: Prolonged increase in insulin-stimulated glucose transport in muscle after exercise. Am.J.Physiol 256:E494-E499, 1989
73. Wojtaszewski,JF, Hansen,BF, Kiens,B, Richter,EA: Insulin signaling in human skeletal muscle: time course and effect of exercise. Diabetes 46:1775-1781, 1997
74. Wojtaszewski,JF, Hansen,BF, Gade, Kiens,B, Markuns,JF, Goodyear,LJ, Richter,EA: Insulin signaling and insulin sensitivity after exercise in human skeletal muscle. Diabetes 49:325-331, 2000
75. Klip,A, Paquet,MR: Glucose transport and glucose transporters in muscle and their metabolic regulation. Diabetes Care 13:228-243, 1990
76. Devlin,JT, Hirshman,M, Horton,ED, Horton,ES: Enhanced peripheral and splanchnic insulin sensitivity in NIDDM men after single bout of exercise. Diabetes 36:434-439, 1987
77. Kelley,DE, Goodpaster,BH: Effects of physical activity on insulin action and glucose tolerance in obesity. Med.Sci Sports Exerc. 31:S619-S623, 1999
78. Fisher,JS, Gao,J, Han,DH, Holloszy,JO, Nolte,LA: Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin. Am.J.Physiol Endocrinol.Metab 282:E18-E23, 2002
79. Burstein,R, Polychronakos,C, Toews,CJ, MacDougall,JD, Guyda,HJ, Posner,BI: Acute reversal of the enhanced insulin action in trained athletes. Association with insulin receptor changes. Diabetes 34:756-760, 1985
80. Houmard,JA, Tyndall,GL, Midyette,JB, Hickey,MS, Dolan,PL, Gavigan,KE, Weidner,ML, Dohm,GL: Effect of reduced training and training cessation on insulin action and muscle GLUT-4. J.Appl.Physiol 81:1162-1168, 1996
81. Mikines,KJ, Sonne,B, Farrell,PA, Tronier,B, Galbo,H: Effect of training on the dose-response relationship for insulin action in men. J.Appl.Physiol 66:695-703, 1989
82. Rodnick,KJ, Haskell,WL, Swislocki,AL, Foley,JE, Reaven,GM: Improved insulin action in muscle, liver, and adipose tissue in physically trained human subjects. Am.J.Physiol 253:E489-E495, 1987
83. Seals,DR, Hagberg,JM, Allen,WK, Hurley,BF, Dalsky,GP, Ehsani,AA, Holloszy,JO: Glucose tolerance in young and older athletes and sedentary men. J.Appl.Physiol 56:1521-1525, 1984
84. Rosenthal,M, Haskell,WL, Solomon,R, Widstrom,A, Reaven,GM: Demonstration of a relationship between level of physical training and insulin-stimulated glucose utilization in normal humans. Diabetes 32:408-411, 1983
85. Mayer-Davis,EJ, D'Agostino,R, Jr., Karter,AJ, Haffner,SM, Rewers,MJ, Saad,M, Bergman,RN: Intensity and amount of physical activity in relation to insulin sensitivity: the Insulin Resistance Atherosclerosis Study. JAMA 279:669-674, 1998
86. Tonino,RP: Effect of physical training on the insulin resistance of aging. Am.J.Physiol 256:E352-E356, 1989
87. Hollenbeck,CB, Haskell,W, Rosenthal,M, Reaven,GM: Effect of habitual physical activity on regulation of insulin- stimulated glucose disposal in older males. J.Am.Geriatr.Soc. 33:273-277, 1985
88. Dengel,DR, Pratley,RE, Hagberg,JM, Rogus,EM, Goldberg,AP: Distinct effects of aerobic exercise training and weight loss on glucose homeostasis in obese sedentary men. J.Appl.Physiol 81:318-325, 1996
89. Eriksson,J, Taimela,S, Koivisto,VA: Exercise and the metabolic syndrome. Diabetologia 40:125-135, 1997
90. Houmard,JA, Shinebarger,MH, Dolan,PL, Leggett-Frazier,N, Bruner,RK, McCammon,MR, Israel,RG, Dohm,GL: Exercise training increases GLUT-4 protein concentration in previously sedentary middle-aged men. Am.J.Physiol 264:E896-E901, 1993
91. Houmard,JA, Hortobagyi,T, Neufer,PD, Johns,RA, Fraser,DD, Israel,RG, Dohm,GL: Training cessation does not alter GLUT-4 protein levels in human skeletal muscle. J.Appl.Physiol 74:776-781, 1993
92. Kahn,SE, Larson,VG, Beard,JC, Cain,KC, Fellingham,GW, Schwartz,RS, Veith,RC, Stratton,JR, Cerqueira,MD, Abrass,IB: Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging. Am.J.Physiol 258:E937-E943, 1990
93. Reitman,JS, Vasquez,B, Klimes,I, Nagulesparan,M: Improvement of glucose homeostasis after exercise training in non- insulin-dependent diabetes. Diabetes Care 7:434-441, 1984
94. Hughes,VA, Fiatarone,MA, Fielding,RA, Kahn,BB, Ferrara,CM, Shepherd,P, Fisher,EC, Wolfe,RR, Elahi,D, Evans,WJ: Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance. Am.J.Physiol 264:E855-E862, 1993
95. Dela,F, Mikines,KJ, von Linstow,M, Secher,NH, Galbo,H: Effect of training on insulin-mediated glucose uptake in human muscle. Am.J.Physiol 263:E1134-E1143, 1992
96. Cox,JH, Cortright,RN, Dohm,GL, Houmard,JA: Effect of aging on response to exercise training in humans: skeletal muscle GLUT-4 and insulin sensitivity. J.Appl.Physiol 86:2019-2025, 1999
97. Houmard,JA, Hickey,MS, Tyndall,GL, Gavigan,KE, Dohm,GL: Seven days of exercise increase GLUT-4 protein content in human skeletal muscle. J.Appl.Physiol 79:1936-1938, 1995
98. Houmard,JA, Shaw,CD, Hickey,MS, Tanner,CJ: Effect of short-term exercise training on insulin-stimulated PI 3- kinase activity in human skeletal muscle. Am.J.Physiol 277:E1055-E1060, 1999
99. Ebeling,P, Bourey,R, Koranyi,L, Tuominen,JA, Groop,LC, Henriksson,J, Mueckler,M, Sovijarvi,A, Koivisto,VA: Mechanism of enhanced insulin sensitivity in athletes. Increased blood flow, muscle glucose transport protein (GLUT-4) concentration, and glycogen synthase activity. J.Clin.Invest 92:1623-1631, 1993
100. Youngren,JF, Barnard,RJ: Effects of acute and chronic exercise on skeletal muscle glucose transport in aged rats. J.Appl.Physiol 78:1750-1756, 1995
101. Rodnick,KJ, Piper,RC, Slot,JW, James,DE: Interaction of insulin and exercise on glucose transport in muscle. Diabetes Care 15:1679-1689, 1992
102. Dela,F, Handberg,A, Mikines,KJ, Vinten,J, Galbo,H: GLUT 4 and insulin receptor binding and kinase activity in trained human muscle. J.Physiol 469:615-624, 1993
103. Bak,JF, Jacobsen,UK, Jorgensen,FS, Pedersen,O: Insulin receptor function and glycogen synthase activity in skeletal muscle biopsies from patients with insulin-dependent diabetes mellitus: effects of physical training. J.Clin.Endocrinol.Metab 69:158-164, 1989
104. Chibalin,AV, Yu,M, Ryder,JW, Song,XM, Galuska,D, Krook,A, Wallberg-Henriksson,H, Zierath,JR: Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: differential effects on insulin-receptor substrates 1 and 2. Proc.Natl.Acad.Sci.U.S.A 97:38-43, 2000
105. Yu,M, Blomstrand,E, Chibalin,AV, Wallberg-Henriksson,H, Zierath,JR, Krook,A: Exercise-associated differences in an array of proteins involved in signal transduction and glucose transport. J.Appl.Physiol 90:29-34, 2001
106. Wadley,GD, Tunstall,RJ, Sanigorski,A, Collier,GR, Hargreaves,M, Cameron-Smith,D: Differential effects of exercise on insulin-signaling gene expression in human skeletal muscle. J.Appl.Physiol 90:436-440, 2001
107. Boule,NG, Haddad,E, Kenny,GP, Wells,GA, Sigal,RJ: Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA 286:1218-1227, 2001
108. Dunstan,DW, Puddey,IB, Beilin,LJ, Burke,V, Morton,AR, Stanton,KG: Effects of a short-term circuit weight training program on glycaemic control in NIDDM. Diabetes Res.Clin.Pract. 40:53-61, 1998
109. Honkola,A, Forsen,T, Eriksson,J: Resistance training improves the metabolic profile in individuals with type 2 diabetes. Acta Diabetol. 34:245-248, 1997
110. Eriksson,J, Taimela,S, Eriksson,K, Parviainen,S, Peltonen,J, Kujala,U: Resistance training in the treatment of non-insulin-dependent diabetes mellitus. Int.J.Sports Med. 18:242-246, 1997
111. Ishii,T, Yamakita,T, Sato,T, Tanaka,S, Fujii,S: Resistance training improves insulin sensitivity in NIDDM subjects without altering maximal oxygen uptake. Diabetes Care 21:1353-1355, 1998
112. Smutok,MA, Reece,C, Kokkinos,PF, Farmer,CM, Dawson,PK, DeVane,J, Patterson,J, Goldberg,AP, Hurley,BF: Effects of exercise training modality on glucose tolerance in men with abnormal glucose regulation. Int.J.Sports Med. 15:283-289, 1994
113. Eriksson,J, Tuominen,J, Valle,T, Sundberg,S, Sovijarvi,A, Lindholm,H, Tuomilehto,J, Koivisto,V: Aerobic endurance exercise or circuit-type resistance training for individuals with impaired glucose tolerance? Horm.Metab Res. 30:37-41, 1998
114. Fluckey,JD, Hickey,MS, Brambrink,JK, Hart,KK, Alexander,K, Craig,BW: Effects of resistance exercise on glucose tolerance in normal and glucose-intolerant subjects. J.Appl.Physiol 77:1087-1092, 1994
115. Schneider,SH, Khachadurian,AK, Amorosa,LF, Clemow,L, Ruderman,NB: Ten-year experience with an exercise-based outpatient life-style modification program in the treatment of diabetes mellitus. Diabetes Care 15:1800-1810, 1992
116. Selam,JL, Casassus,P, Bruzzo,F, Leroy,C, Slama,G: Exercise is not associated with better diabetes control in type 1 and type 2 diabetic subjects. Acta Diabetol. 29:11-13, 1992
117. Roberts,L, Jones,TW, Fournier,PA: Exercise training and glycemic control in adolescents with poorly controlled type 1 diabetes mellitus. J.Pediatr.Endocrinol.Metab 15:621-627, 2002
118. Ligtenberg,PC, Blans,M, Hoekstra,JB, van,dT, I, Erkelens,DW: No effect of long-term physical activity on the glycemic control in type 1 diabetes patients: a cross-sectional study. Neth.J.Med. 55:59-63, 1999
119. Lehmann,R, Kaplan,V, Bingisser,R, Bloch,KE, Spinas,GA: Impact of physical activity on cardiovascular risk factors in IDDM. Diabetes Care 20:1603-1611, 1997
120. Mosher,PE, Nash,MS, Perry,AC, LaPerriere,AR, Goldberg,RB: Aerobic circuit exercise training: effect on adolescents with well- controlled insulin-dependent diabetes mellitus. Arch.Phys.Med.Rehabil. 79:652-657, 1998