Table of Contents

INTRODUCTION

TREATMENT GOALS

SULFONYLUREAS

Mechanism of Action

Efficacy

Side Effects

MEGLITINIDES: REPAGLINIDE AND NATEGLINIDE

Mechanism of Action

Efficacy

Side Effects

METFORMIN

Mechanism of Action

Efficacy

Side Effects and Contraindications

THIAZOLIDINEDIONES: PIOGLITAZONE AND ROSIGLITAZONE

Mechanism of Action

Efficacy

Side Effects

α-GLUCOSIDASE INHIBITORS

Mechanism of Action

Efficacy

Side Effects

EMERGING APPROACHES

Dipeptidyl Peptidase IV (DPP-IV) Inhibition

Selective Cannabinoid-1 Receptor (CB-1) Antagonism

PERSPECTIVES