Table of Contents

I. INTRODUCTION

II. ANATOMY AND PHYSIOLOGY

III. NATURAL HISTORY OF PROSTATE DISEASE

IV. BASIC SCIENCE OF PROSTATE CANCER

(i) Introduction

A Genetics of Prostate Cancer

B. Stromal Epithelial Interaction in Prostate Cancer

C. Molecular Markers of Prostate Cancer.

D Future Directions

V. PREVENTION OF PROSTATE CANCER

Introduction

Dietary & Natural Therapies

Pharmacological

Conclusion

VI. DIAGNOSING PROSTATE CANCER

A. Introduction

B. Making Decisions about whether or not to diagnose Prostate cancer

Supporting Patient Choice about Testing for Prostate cancer

C. Digital Rectal Examination

D. Prostate-specific Antigen (PSA)

E. Prostatic Fluid

F. Prostate Needle Biopsies

G. Histologic Analysis

VII. PROSTATE CANCER TREATMENT OPTIONS

A. Introduction

B. Pre-treatment decision-making

C. Clinical staging

D. Management Options

E. Sexuality and prostate cancer

VIII. RADICAL RETROPUBIC PROSTATECTOMY (RRP)

A. Preoperative Consultation and Care

B. Operative Technique

C Nerve-sparing prostatectomy

D. Pelvic Lymphadenectomy

IX. RESULTS OF RADICAL RETROPUBIC PROSTATECTOMY

A. Disease-free Recurrence and Survival

X. COMPLICATIONS OF RADICAL RETROPUBIC PROSTATECTOMY

A. Incontinence

B. Impotence (& sexual dysfunction – see section VII. E)

C. Bleeding

D. Infection

E. Visceral Injuries

F. Deep vein thrombosis, pulmonary embolus & other problems

XI. TREATMENT OF POST-PROSTATECTOMY RECURRENCES

Adjuvant radiotherapy

Salvage radiotherapy

XII. RADIOTHERAPY

A. Introduction

B. Stratification of risk of progression & metastases

C. External Beam Radiotherapy

D. Brachytherapy

E. Defining biochemical failure (BF) after radiotherapy

F. Management of local failure after radiotherapy

G. Quality of life issues in prostate cancer radiotherapy

XIII. SYSTEMIC THERAPIES

A. Hormonal Therapy

B. Chemotherapy

C Bisphosphonates

D Bone-seeking radio-isotopes

E. Emerging Therapies: Vaccines in Prostate cancer

XVII. CONCLUSIONS

References