Table of Contents

Outline

CHANGES IN THE STEROIDOGENIC COMPARTMENT OF THE TESTIS

Age Related Changes in Circulating Concentrations of Reproductive Hormones

Prevalence of Low Testosterone Levels in Middle-Aged and Older Men

Mechanisms of Age-Related Decline in Testosterone Levels

Physiological and Clinical Correlates of Age-Related Decline in Circulating Testosterone in Epidemiological Studies

Potential Beneficial Effects of Testosterone Replacement in Older Men with Low Testosterone Levels

Considerations in Testosterone Therapy of Older Men with Low Testosterone Levels

Risks of Testosterone Administration in Older Men

CHANGES IN THE GAMETOGENIC COMPARTMENT OF THE TESTIS

Changes in fertility of older men

Changes in the Germ Cell Compartment

Changes in Supportive Cells and Accessory Glands

Epigenetic and Aneuploidic Changes in Offspring of older men

Conclusion