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	INTRODUCTION
	AETIOLOGY OF HYPOPITUITARISM
	CONGENITAL
	HESX-1 MUTATIONS
	PIT-1 DEFECT
	PROP-1 DEFECT
	KAL
	DAX-1
	GH1 GENE MUTATIONS
	TUMOURS
	Pituitary Adenoma
	Craniopharyngiomas
	Rathke's cysts
	Peripituitary tumours
	VASCULAR
	INFLAMMATORY LESIONS
	INFECTIONS
	RADIATION THERAPY
	EMPTY SELLA SYNDROME
	CLINICAL MANIFESTATION OF HYPOPITUITARISM
	GROWTH HORMONE DEFICIENCY
	ADRENOCORTI- COTROPHIC HORMONE DEFICIENCY
	LUTEINIZING HORMONE AND FOLLICLE STIMULATING HORMONE DEFICIENCY
	THYROID STIMULATING HORMONE DEFICIENCY
	PROLACTIN
	ANTIDIURETIC HORMONE DEFICIENCY
	INVESTIGATION OF SUSPECTED HYPOPITUITARISM
	BASELINE INVESTIGATIONS
	DYNAMIC TESTING
	Hypothalamo- pituitary-adrenal axis
	Growth Hormone
	Pituitary- Thyroid axis
	POSTERIOR PITUITARY FUNCTION
	IMAGING THE PITUITARY
	MANAGEMENT OF HYPOPITUITARISM
	HYPOADRENALISM
	SECONDARY HYPOTHYROIDISM
	GONADOTROPHIN DEFICIENCY
	Women
	Men
	Monitoring testosterone replacement
	DIABETES INSIPIDUS
	GROWTH HORMONE DEFICIENCY