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	INTRODUCTION
	CAUSES OF GH DEFICIENCY IN ADULTS
	THE DIAGNOSIS OF GH DEFICIENCY
	CLINICAL FEATURES OF GH DEFICIENCY IN ADULTS
	RESPONSE TO GH REPLACEMENT IN ADULT GROWTH HORMONE DEFICIENCY
	QUALITY OF LIFE AND PSYCHOLOGICAL WELL-BEING
	BODY COMPOSITION: FAT MASS, FAT DISTRIBUTION AND LEAN BODY MASS
	EXERCISE CAPACITY AND PERFORMANCE
	CARBOHYDRATE METABOLISM AND INSULIN SENSITIVITY
	SERUM LIPOPROTEIN PROFILES
	CARDIAC AND PERIPHERAL VASCULAR EFFECTS
	INDICES OF BONE REMODELLING AND BONE MINERAL DENSITY
	SELECTING PATIENTS FOR GROWTH HORMONE REPLACEMENT
	ESTABLISHING THE MAINTENANCE GH DOSE
	ADVERSE EFFECTS
	GH REPLACEMENT IN ELDERLY HYPOPITUITARY PATIENTS
	TRANSITION BETWEEN PAEDIATRIC AND ADULT CARE FOR CHILDHOOD ONSET GHD
	COSTS VERSUS BENEFITS OF GH REPLACEMENT THERAPY
	TREATMENT COSTS
	ECONOMIC BENEFITS OF GH REPLACEMENT