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	INTRODUCTION
	Spontaneous obesity in rodents is caused by monogenic and polygenic mutations
	Spontaneous and genetically manipulated rodent models illustrate fundamental aspects of the molecular physiology of body weight regulation
	Transgenic models of control of body composition
	SPONTANEOUSLY OCCURRING MOUSE MUTATIONS LEADING TO OBESITY
	TRANSGENIC MODELS OF OBESITY
	Obesity Due Primarily to Increased Food Intake
	Obesity Primarily Due to Decreases in Energy Expenditure
	Obesity Primarily Due to Altered Partitioning of Food Substrates
	Obesity Due Primarily to a Defect in Partitioning
	CONCLUSIONS