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	ETIOLOGIC CLASSIFICATION
	Type 1 Diabetes
	Type 2 Diabetes
	Genetic Defects of ß-cell
	Genetic Defects in Insulin Action
	Endocrinopathies
	Drug- or Chemical- induced Diabetes
	Viral Infections
	Uncommon forms of Immune- mediated Diabetes
	NATURAL HISTORY OF HUMAN TYPE-1 DIABETES
	Structure and Functions of Pancreas
	Metabolic Derangements of Type-1 Diabetes
	Genetic Susceptibility
	Autoantigens and Autoantibodies
	Antigen Specific Cellular Immunity
	PATHOGENESIS OF IMD
	THE INDUCTIVE EVENT
	Molecular Mimicry
	Superantigens
	DEFICIENCIES IN IMMUNOREGULATION IN TYPE 1 DIABETES
	ENVIRONMENTAL FACTORS
	ROLE OF DIET
	SCREENING METHODS AND PREVENTION OF T1DM
	Type-1A T1DM Prevention Trial
	TREATMENT OF TYPE 1 DIABETES
	Clinical Management
	IMD Prevention Trials
	Transplantation of the Pancreas
	INSULIN RESISTANCE SYNDROME (IRS)
	Natural history of IRS
	Underlying mechanisms of IRS
	Treatment
	TYPE-2 DIABETES
	SUMMARY